Methyl 2-(trifluoromethyl)nicotinate

Methyl 2-(trifluoromethyl)nicotinate - Names and Identifiers

Name	Methyl 2-(trifluoromethyl)nicotinate
Synonyms	Methyl 2-(trifluoromethyl)nicotite Methyl 2-(trifluoromethyl)nicotinate 2-Trifluoromethyl-nicotinic acid methyl ester Methyl 2-(trifluoromethyl)-3-pyridinecarboxylate Methyl 2-(trifluoroMethyl)pyridine-3-carboxylate methyl 2-(trifluoromethyl)pyridine-3-carboxylate 3-Pyridinecarboxylic acid, 2-(trifluoroMethyl)-, ethyl ester 3-Pyridinecarboxylic acid, 2-(trifluoromethyl)-, methyl ester
CAS	136483-17-5
InChI	InChI=1/C8H6F3NO2/c1-14-7(13)5-3-2-4-12-6(5)8(9,10)11/h2-4H,1H3

Methyl 2-(trifluoromethyl)nicotinate - Physico-chemical Properties

Molecular Formula	C8H6F3NO2
Molar Mass	205.13
Density	1.331±0.06 g/cm3(Predicted)
Boling Point	216.7±40.0 °C(Predicted)
Flash Point	84.8°C
Vapor Presure	0.138mmHg at 25°C
pKa	-1.48±0.22(Predicted)
Storage Condition	2-8°C
Refractive Index	1.446

Methyl 2-(trifluoromethyl)nicotinate - Introduction

Methyl 2-trifluoromethylnicotinate is a chemical substance with the chemical formula CF3C(O)OCH3. The following is a description of its nature, use, preparation and safety information:

Nature:
2-Trifluoromethyl nicotinic acid methyl ester is a colorless liquid with a special smell. It has a low density and can be dissolved in some organic solvents. It is an unstable compound that easily decomposes and produces harmful gases.

Use:
2-Trifluoromethyl nicotinic acid methyl ester is widely used in organic synthesis. It can be used as an intermediate for pesticides, pharmaceuticals and other chemicals. It can also be used to prepare fluorinated organic compounds, such as fluorinated acids, esters and amides.

Preparation Method:
The preparation of methyl 2-trifluoromethylnicotinate generally uses the reaction of methyl nicotinate and trifluoroformic acid. The reaction is typically carried out at low temperatures and in an inert atmosphere to prevent uncontrolled side reactions. The preparation process requires careful handling because methyl 2-trifluoromethylnicotinate is harmful.

Safety Information:
2-trifluoromethyl nicotinic acid methyl ester is a harmful substance. When manipulating it, appropriate protective measures need to be taken, including wearing protective gloves, goggles and protective clothing. Avoid contact with skin, eyes and clothing. When using it, it should be operated in a well-ventilated place to avoid its vapor entering the respiratory system. When handling this compound, be careful to prevent ignition and high temperatures. If inhaled, ingested or in contact with skin, seek medical attention immediately.

Last Update：2024-04-09 02:00:42